Selective cytotoxic effect of Annona muricataL. in HCC1954 (HER2+) breast cancer cells

Annona muricataLinn. (Annonaceae) is a tropical plant with multiple beneficial health effects including anticancer properties. In breast cancer patients, overexpression of the HER2 oncoprotein corresponds to poor prognosis, thus main purpose this study was evaluate cytotoxicity ethanolic extracts from dried and fresh leaf A. muricataon HER2+ cells. MTT assays were performed IC50determined in HCC1954 (HER2+) cells, as well MCF7 (HER-) peripheral blood mononuclear cells (PBMC) used controls. Total polyphenol content evaluation phytochemical screening also performed. The cytotoxic effect muricataextracts (125-1000 μg/mL) dose-dependent cell-type specific. exhibited higher against than but weak toxicity PBMC. This first report highlighting its potential for treating anti-estrogen-resistant cancers low